INVESTIGATING DYNAMICS OF AGE-ASSOCIATED TRANSCRIPTIONAL NETWORKS WITH INTERVENTIONS TARGETING AGING
نویسندگان
چکیده
منابع مشابه
Targeting chromatin aging - The epigenetic impact of longevity-associated interventions.
A rapidly growing body of evidence has shown that chromatin undergoes radical alterations as an organism ages, but how these changes relate to aging itself is an open question. It is likely that these processes contribute to genomic instability and loss of transcriptional fidelity, which in turn drives deleterious age-related phenotypes. Interventions associated with increased healthspan and lo...
متن کاملTargeting Interventions in Networks
Individuals interact strategically with their network neighbors, as in effort investment with spillovers among peers, or production decisions among firms connected by a supply chain. A planner can shape their incentives in pursuit of some goal—for instance, maximizing utilitarian welfare or minimizing the volatility of aggregate activity. We offer an approach to solving such intervention proble...
متن کاملWill interventions targeting conscientiousness improve aging outcomes?
The articles appearing in this special section discuss the role that conscientiousness may play in healthy aging. Growing evidence suggests that conscientious individuals live longer and healthier lives. However, the question remains whether this personality trait can be leveraged to improve long-term health outcomes. We argue that even though it may be possible to design therapeutic interventi...
متن کاملTranscriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts.
To provide a global analysis of gene expression in the aging heart, we monitored the expression of 9,977 genes simultaneously in 5- and 30-month-old male B6C3F(1) mice by using high-density oligonucleotide microarrays and several statistical techniques. Aging was associated with transcriptional alterations consistent with a metabolic shift from fatty acid to carbohydrate metabolism, increased e...
متن کاملFruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits.
Nutritional interventions, in this case, increasing dietary intake of fruits and vegetables, can retard and even reverse age-related declines in brain function and in cognitive and motor performance in rats. Our lab has shown that as Fischer 344 rats age their brains are increasingly vulnerable to oxidative stress. Dietary supplementation with fruit or vegetable extracts high in antioxidants (e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2019
ISSN: 2399-5300
DOI: 10.1093/geroni/igz038.2066